🧬 Project Description:
This project focuses on leveraging genome-wide CRISPR screens to uncover vulnerabilities in T-ALL cell lines under chemotherapy stress. So far, such screening under these conditions remains unexplored, particularly due to the challenge of maintaining Cas9 expression in T-ALL cells.
The research aims to:
- Validate screen hits in T-ALL lines treated with chemotherapy.
- Use targeted drugs against CRISPR-identified genes.
- Explore mechanisms of resistance.
- Develop novel combinatorial treatment strategies.
🧫 About the Lab:
- Metabolism in T-cell leukemias.
- The interaction between metabolic pathways and gene regulation.
- Flow cytometry.
- Patient-derived cell cultures.
- In vitro and in vivo pharmacodynamics.
- CRISPR screens.
- RNA-seq, ATAC-seq, and ChIP-seq.
✅ Required Qualifications:
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Background in Immunology or Molecular Biology
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Experience with metabolism or leukemia is preferred
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Strong motivation, enthusiasm, and team spirit
Excellent written and spoken English
📤 How to Apply:
- Send your application to Marissa Rashkovan at:
- 📧 marissa.rashkovan.hsj@ssss.gouv.qc.ca
- Required Documents:
- Curriculum Vitae (CV)
- Motivation Letter
- References
- Academic transcripts (PhD applicants only)
⏳ Deadline:
Applications are reviewed on a rolling basis until the position is filled.Benefits of This Research Opportunity – Rashkovan Lab, Université de Montréal
1. State-of-the-Art Research Environment You’ll be working at the cutting edge of biomedical research using genome-wide CRISPR screening, RNA-seq, ATAC-seq, and ChIP-seq—technologies that are changing cancer research worldwide.
2. High-Impact Disease The project is focused on T-cell acute lymphoblastic leukemia (T-ALL), a very aggressive childhood cancer. Your work could lead to new treatments for this life-threatening disease.
3. Interdisciplinary Training You’ll learn molecular biology, cancer metabolism, immunology, and epigenetics, making you a well-rounded scientist with an edge in academia or biotech.
4. Real-World Clinical Relevance You’ll work with patient-derived cell lines and combine lab results with chemotherapy treatments to bridge the gap between basic science and clinical applications.
5. Personalized Mentorship You’ll join a new lab under the supervision of Dr. Marissa Rashkovan and have the opportunity to contribute to the lab’s early growth and direction.
6. Academic Environment Located at the CHU Sainte-Justine Research Center, affiliated with the Université de Montréal, you’ll be surrounded by top experts, labs and collaborative projects.
7. Funding and Resources Although not specified, opportunities like this usually come with competitive stipends, access to core facilities and conference travel funding, especially in Canadian research institutions.
8. Career Advancement This position will boost your academic and professional profile:
Publications in high-impact journals
Conference presentations
Grant writing and scientific communication training
9. Cultural and International Exposure Living and working in Montréal, one of North America’s most diverse and cosmopolitan cities, offers a rich social and cultural experience and access to top research infrastructure.
10. Rolling Applications – No Deadlines You can apply whenever you’re ready and we’ll consider your application as soon as possible, no stress!